Wet Granulation Production Line
Elevate your tablet production with our advanced tablet press solutions.
Wet Granulation Production Line
Elevate your tablet production with our advanced tablet press solutions.
The wet granulation production line is a core process in the pharmaceutical industry, widely used for manufacturing tablets, capsules, and other solid dosage forms. This process involves mixing powder materials with a binder solution to form wet granules, followed by drying, sizing, and final compression or coating.
Wet Granulation Production Line
1.HLSG (High-Speed Wet Granulator)
2.FL Fluid Bed Granulator (Integrated Granulation and Drying Machine)
3.PGL Lifting Vacuum Cone Mill
4.HTD Multi-Dimensional Motion Mixer
5.Tablet Press
6.BG Coating Machine
Overview
The wet granulation production line is a sophisticated system designed to efficiently produce high - quality granules, which are widely used in various industries such as pharmaceuticals, chemicals, and food. This production line integrates a series of advanced equipment, each playing a crucial role in the granulation process, ensuring the stability, uniformity, and quality of the final products.
The HLSG (High - Speed Wet Granulator) serves as the cornerstone of the wet granulation process. By virtue of its high - speed rotating impeller, it efficiently blends solid materials with liquid binders. The impeller's high speed creates a strong shearing and mixing force, which ensures that the materials and binders are mixed rapidly and uniformly. This rapid and uniform mixing action promotes the formation of primary granules, laying a solid foundation for subsequent processing steps. Its high efficiency ensures that the granulation process is completed in a short time, improving the overall production efficiency. Moreover, the HLSG is highly adaptable to different types of materials and binders, making it suitable for a wide range of production requirements.
The FL Fluid Bed Granulator, an integrated granulation and drying machine, plays a vital role in the production line. After the primary granules are formed in the HLSG, they are transferred to this equipment. Here, under the action of hot air flow, the granules are fluidized, allowing for further granulation and simultaneous drying. The fluidization state ensures that each granule is evenly exposed to the hot air, resulting in uniform drying. This integration of processes not only reduces the number of production steps but also ensures that the granules have uniform moisture content, enhancing the quality of the final product. Additionally, the FL Fluid Bed Granulator offers precise control over parameters such as air flow, temperature, and granulation time, enabling operators to adjust the process according to specific product requirements.
The PGL Lifting Vacuum Cone Mill is responsible for sizing and refining the granules after the granulation and drying process. It uses a conical screen and a rotating impeller to crush and sieve the granules. The lifting function allows for easy loading and unloading of materials, improving operational convenience. The vacuum system in the mill helps to prevent the escape of dust, creating a clean working environment and reducing material loss. This equipment ensures that the granules have a uniform particle size distribution, which is essential for subsequent processing steps such as tableting. It can also be adjusted to produce granules of different particle sizes, meeting various production needs.
After sizing, the granules may need to be mixed with other additives or excipients to ensure uniform distribution of components. The HTD Multi - Dimensional Motion Mixer achieves this through its unique multi - dimensional movement. Unlike traditional mixers that only rotate in one direction, this mixer moves in multiple directions, such as rotation, revolution, and rocking, which promotes thorough mixing of the materials. This multi - dimensional motion ensures that even small amounts of additives are evenly distributed throughout the granule mixture, improving the consistency and quality of the final product. The mixer has a large capacity and high mixing efficiency, making it suitable for large - scale production.
The Tablet Press is used to compress the mixed granules into tablets of specific shapes and sizes. It works by applying high pressure to the granules in a die cavity, causing them to bond together. The Tablet Press is equipped with precise control systems to ensure that the tablets have uniform weight, hardness, and thickness. It can produce tablets at a high speed, meeting the demands of mass production. The machine is also easy to operate and maintain, reducing downtime and improving production efficiency.
For some products, a coating is required to improve their stability, taste, or appearance. The BG Coating Machine is designed for this purpose. It applies a coating solution to the surface of the tablets in a controlled manner. The tablets are rotated in a drum, and the coating solution is sprayed onto them, forming a uniform coating layer as the solvent evaporates. The BG Coating Machine offers precise control over coating thickness, uniformity, and drying conditions, ensuring that the coated tablets meet the required quality standards. It is suitable for a variety of coating materials, including polymers, sugars, and pigments.
The working process of the wet granulation production line starts with the feeding of raw materials into the HLSG. In the HLSG, the raw materials are mixed with binders to form primary granules. These primary granules are then transferred to the FL Fluid Bed Granulator, where they undergo further granulation and drying under the action of hot air. After drying, the granules are sent to the PGL Lifting Vacuum Cone Mill for sizing and refining to achieve a uniform particle size. The sized granules are then transported to the HTD Multi - Dimensional Motion Mixer, where they are mixed with additives or excipients to ensure uniform component distribution. The mixed granules are fed into the Tablet Press, which compresses them into tablets. Finally, the tablets are sent to the BG Coating Machine for coating if necessary, resulting in the final product.
High production efficiency: The integration of various equipment and the automation of the production process reduce manual operations and production time, improving overall production efficiency.
Stable product quality: Each equipment in the production line offers precise control over process parameters, ensuring the uniformity and stability of the granules and final products.
Strong adaptability: The production line can handle a wide range of materials and meet different production requirements by adjusting process parameters and equipment settings.
Clean production environment: The use of vacuum systems and dust - proof designs in equipment such as the PGL Lifting Vacuum Cone Mill ensures a clean working environment, reducing material contamination.
In conclusion, the wet granulation production line consisting of HLSG, FL Fluid Bed Granulator, PGL Lifting Vacuum Cone Mill, HTD Multi - Dimensional Motion Mixer, Tablet Press, and BG Coating Machine provides an efficient, reliable, and high - quality solution for granule production in various industries.
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